Turcot syndrome

Causes

What gene mutation causes Turcot syndrome?

Turcot syndrome comes from having a mutation in one of the following genes: APC, MLH1, or PMS2. The APC gene is associated with a condition called familial adenomatous polyposis, and the MLH1 and PMS2 genes are associated with a different condition called Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC).

References
  • https://rarediseases.info.nih.gov/gard/420/turcot-syndrome/resources/1
Show More Content Like This

More Causes Content

What does mismatch repair deficiency mean?

Is Turcot syndrome a predisposition or a cause?

What does mismatch repair deficiency mean?

Mismatch repair is a process the body uses to repair damage to DNA. Damaged DNA can cause tumors to grow. Using mismatch repair corrects damage done to DNA to prevent a tumor from growing. Sometimes a mutation (change in DNA sequence) causes the parts of the mismatch repair system not to work, which means that it cannot fix other mutations. This leads to a higher chance of having a tumor grow.

References
  • http://www.hhmi.org/biointeractive/mismatch-repair
Is Turcot syndrome a predisposition or a cause?

Turcot syndrome is a predisposition to certain types of cancer, primarily colon and brain. Having Turcot syndrome gives a person a higher chance of developing cancer, but is not a certainty.

References
  • http://www.omim.org/entry/276300
  • http://www.cancer.net/cancer-types/turcot-syndrome

We use cookies to ensure that we give you the best experience on our website. By continuing to browse this site, you are agreeing to our use of cookies.

Continue Find out more about our use of cookies and similar technology

This content comes from a hidden element on this page.

The inline option preserves bound JavaScript events and changes, and it puts the content back where it came from when it is closed.

Remember Me