Trisomy 13

Inheritance

What is the chance to have another child with Trisomy 13?

If neither parent has a chromosome rearrangement, the chance to have a second baby with trisomy 13 is thought to be low, but not impossible. If there is a suspicion of trisomy 13 in a baby, it is important to confirm this with genetic testing so the most accurate recurrence risk (the chance that the couple will have another baby with the same condition) can be provided. There is around a 1% chance to have a second child with trisomy 13 or another trisomy, such as trisomy 21 or trisomy 18. The chance to have a child with trisomy 13 increases as a women ages. Even though trisomy 13 is rare, it is seen more frequently in babies born to women in their late 30s and early 40s, as compared to babies born to younger women. Prenatal testing is available and is generally offered to interested parents through their healthcare providers caring for them during pregnancy. Prenatal genetic counselors can also provide individualized information about the possibility of having another pregnancy with a chromosome problem.

http://ghr.nlm.nih.gov/condition/trisomy-13

Baty, B.J., Blackburn, B.L., and Carey, J.C. Natural History of Trisomy 18 and Trisomy 13: I. Growth, Physical Assessment, Medical Histories, Survival, and Recurrence Risk. American Journal of Medical Genetics. 1994; 49: 175-188

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