Sideroblastic anemia

Overview

What is sideroblastic anemia?

Sideroblastic anemia is a rare blood disorder that makes the body unable to produce healthy red blood cells. In this condition, individuals will have an accumulation of iron in their red blood cells specifically in the mitochondria of the cell. This buildup is due to the mitochondria's inability to process the iron and gives the cells a ring shaped appearance that doctors are able to identify as sideroblastic anemia through a blood test. The most common signs of sideroblastic anemia is fatigue, breathing difficulties, weakness and occasionally enlargement of the liver and spleen. This condition can be caused due to a genetic cause or an acquired cause.

SOURCE: Emory University - Department of Human Genetics in collaboration with ThinkGenetic • https://www.thinkgenetic.com/diseases/sideroblastic-anemia-109949/overview/67534 • DATE UPDATED: 2019-03-20

References

Bottomley, S. S., & Fleming, M. D. (2014). Sideroblastic anemia: diagnosis and management. Hematol Oncol Clin North Am, 28(4), 653-670, v. doi:10.1016/j.hoc.2014.04.008

Ashorobi D, Chhabra A. Sideroblastic Anemia. [Updated 2019 Feb 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538287/

Harigae, H., & Furuyama, K. (2010). Hereditary sideroblastic anemia: pathophysiology and gene mutations. Int J Hematol, 92(3), 425-431. doi:10.1007/s12185-010-0688-4

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