Paragangliomas

Overview

What is a paraganglioma?

Paragangliomas are noncancerous tumors of the peripheral nervous system (the nerves that are not part of the brain and spinal cord). They can occur in any nerve and often near a major artery. The most common site paragangliomas develop is in the abdomen where approximately 85-90% are located. Sometimes paragangliomas release hormones like noradrenaline or adrenaline that cause a high blood pressure, hot flashes, racing heartbeat, and headaches, other times they do not. Most of the time paragangliomas occur as sporadic tumors, that is, they are not inherited. Paragangliomas may also be surgically removed if they are secreting hormones, causing a health problem such making it difficult to breathe, or have become cancerous. Paragangliomas can occur as a isolated finding or part of a genetic conditions such as multiple endocrine neoplasia (MEN) type 2, von Hippel-Lindau syndrome, or Neurofibromatosis type 1.

References
Show More Content Like This

More Overview Content

What do you call a paraganglioma?

How many people have paragangliomas?

What conditions have paragangliomas?

What are paragangliomas seen with?

What do you call a paraganglioma?

Paragangliomas can also be called PGLs. Less commonly they may be referred to as a chemodectoma. When paragangliomas are caused by an identified genetic condition, it is common to refer to the situation by the gene name or genetic condition. For example, Familial paraganglioma syndome (FPGL) or SDHD related paragangliomas. They may also be called pheochromocytomas; however, paragangliomas that arise in the adrenal medulla are defined as pheochromocytomas, and those outside the adrenal gland are called paragangliomas.

References
How many people have paragangliomas?

About 1 person per 100,000 will be diagnosed with paraganglioma per year. It is more commonly seen in individuals who are between 30-40 years old.

References
  • de Paula Miranda, E., Lopes, R. I., Padovani, G. P., Moscardi, P. R., Nishimura, F. G., de Mendonça, B. B., ... Denes, F. T. (2016). Malignant paraganglioma in children treated with embolization prior to surgical excision. World journal of surgical oncology, 14(1), 26. doi:10.1186/s12957-016-0778-8
  • (2011). Nonsyndrome paragangliomas. Genetic Home Reference. Retrieved on February 19, 2019 from https://ghr.nlm.nih.gov/condition/nonsyndromic-paraganglioma#synonyms
What conditions have paragangliomas?

Paragangliomas can occur as a isolated finding or part of a genetic conditions such as multiple endocrine neoplasia (MEN) type 2, von Hippel-Lindau syndrome, Neurofibromatosis type 1, or Familial Paraganglioma Syndrome.

References
What are paragangliomas seen with?

Paragangliomas may also occur simultaneously with pheochromocytomas and may occasionally occur as multiple tumors.

References
  • Else, T., Greenberg, S., & Fishbein, L. (2008). Hereditary paraganglioma-pheochromocytoma syndromes. Gene Reviews. Retrieved on February 19, 2019 from https://www.ncbi.nlm.nih.gov/books/NBK1548/.
  • The American Association of Endocrine Surgeons Patient Education Site, Paraganglioma (adrenaline-producing tumor outside the adrenal gland), http://endocrinediseases.org/adrenal/paraganglioma.shtml Accessed 28NOV19.

We use cookies to ensure that we give you the best experience on our website. By continuing to browse this site, you are agreeing to our use of cookies.

Continue Find out more about our use of cookies and similar technology

This content comes from a hidden element on this page.

The inline option preserves bound JavaScript events and changes, and it puts the content back where it came from when it is closed.

Remember Me