Ornithine transcarbamylase (OTC) deficiency

Living with

What can trigger hyperammonemic episodes in people with Ornithine Transcarbamylase Deficiency?

Anything that places increased stress on the body of someone with ornithine transcarbamylase deficiency can trigger an hyperammonemic episode. Viral infections are probably the most common cause, but episodes can be triggered by physical or emotional stress, dehydration, trauma, broken bones, the menstrual cycle, certain medications (like Valproic acid), pregnancy and delivery, and changes in the diet.


Lichter-Konecki U, Caldovic L, Morizono H, et al. Ornithine Transcarbamylase Deficiency. 2013 Aug 29 [Updated 2016 Apr 14]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019. Available from: https://www.ncbi.nlm.nih.gov/books/NBK154378/

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