Mucopolysaccharidosis Type VI


What gene change causes Mucopolysaccharidosis Type VI?

Mucopolysaccharidosis Type VI (MPS VI) is caused by genetic changes in the ARSB gene. These changes in ARSB prevent normal production of an enzyme called arylsulfatase B in the body. This lack of arylsulfatase B causes the buildup of glycosaminoglycans (GAGs) in different parts of the body, which is what creates health problems for people with MPS VI. GAGs were originally called mucopolysaccharides, which is where this condition gets its name. There are several other types of MPS disorders caused by different genes. Only changes in ARSB cause MPS VI.

Genetics Home Reference -

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