Alpha-mannosidosis

Symptoms

Are there earlier onset, later onset, or variant forms of Alpha-mannosidosis?

There are three different forms of Alpha-mannosidosis. Alpha-mannosidosis type 1 is a mild form of the condition where people usually show signs after 10 years of age and do not have skeletal abnormalities, but do have muscle weakness with a slow progression of the disease. Alpha-mannosidosis type 2 is a moderate form of the condition where people usually show signs before age 10 and do have skeletal problems, muscle weakness, as well as a slowly progressing disease. Alpha-mannosidosis type 3 is the most severe form of the condition. Alpha-mannosidosis type 3 is where people with this condition usually die before birth or at a young age because of progressive problems with the brain and other parts of the nervous system.

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