Lynch syndrome

Overview

How common is Lynch syndrome?

Lynch syndrome is the most common cause of hereditary colorectal cancer. More specifically, Lynch syndrome accounts for 2-4% of all colorectal cancers. Less than 1% of the general population (1 in 440 people) has a genetic change, or mutation, in a gene associated with Lynch syndrome.

SOURCE: Emory University - Department of Human Genetics in collaboration with ThinkGenetic • https://www.thinkgenetic.com/diseases/lynch-syndrome-i/overview/2187 • DATE UPDATED: 2020-01-09

References

Lynch syndrome. [Internet]. Genetics Home Reference. [Reviewed January 2020]. Available from: http://ghr.nlm.nih.gov/condition/lynch-syndrome

Chen S, Wang W, Lee S, Nafa K, Lee J, Romans K, Watson P, Gruber SB, Euhus D, Kinzler KW, Jass J, Gallinger S, Lindor NM, Casey G, Ellis N, Giardiello FM, Offit K, Parmigiani G. Colon Cancer Family Registry. Prediction of germline mutations and cancer risk in the Lynch syndrome. JAMA. 2006;296:1479-87.

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