Lynch syndrome


What is Lynch syndrome?

Lynch syndrome is a cancer condition caused by genetic changes in the MLH1, MSH2, MSH6, PMS2, or EPCAM genes. Genetic changes in these genes can be passed from parent to child. In other words, Lynch syndrome runs in families. Lynch syndrome is the most common cause of hereditary colon cancer. People with a genetic change in a gene associated with Lynch syndrome have an increased risk for certain types of cancer, including colorectal, uterine, ovarian, and stomach cancers. Both men and women can have Lynch syndrome.

Lynch syndrome. [Internet]. Genetics Home Reference. [Reviewed January 2020]. Available from:

Kohlmann W, Gruber SB. Lynch Syndrome. 2004 Feb 5 [Updated 2018 Apr 12]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2020. Available from:

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