Lynch syndrome


What gene changes cause Lynch syndrome?

Genetic changes, or mutations, in the MLH1, MSH2, MSH6, PMS2, and EPCAM genes cause Lynch syndrome. There are numerous changes in each of these genes that can cause Lynch syndrome.

SOURCE: Emory University - Department of Human Genetics in collaboration with ThinkGenetic • • DATE UPDATED: 2020-01-09


Lynch syndrome. [Internet]. Genetics Home Reference. [Reviewed January 2020]. Available from:

Kohlmann W, Gruber SB. Lynch Syndrome. 2004 Feb 5 [Updated 2018 Apr 12]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2020. Available from:

This content comes from a hidden element on this page.

The inline option preserves bound JavaScript events and changes, and it puts the content back where it came from when it is closed.

Remember Me