Lynch syndrome

Causes

What gene changes cause Lynch syndrome?

Genetic changes, or mutations, in the MLH1, MSH2, MSH6, PMS2, and EPCAM genes cause Lynch syndrome. There are numerous changes in each of these genes that can cause Lynch syndrome.

SOURCE: Emory University - Department of Human Genetics in collaboration with ThinkGenetic • https://www.thinkgenetic.com/diseases/lynch-syndrome-i/causes/2189 • DATE UPDATED: 2020-01-09

References

Lynch syndrome. [Internet]. Genetics Home Reference. [Reviewed January 2020]. Available from: http://ghr.nlm.nih.gov/condition/lynch-syndrome

Kohlmann W, Gruber SB. Lynch Syndrome. 2004 Feb 5 [Updated 2018 Apr 12]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1211/

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