Congenital insensitivity to pain


Is there a treatment(s) for congenital insensitivity to pain?

Congenital insensitivity to pain cannot be cured. Because affected people do not feel pain, preventing injuries and finding injuries quickly is important. To encourage prompt detection of injuries, patient/parents should conduct daily self-checks particularly of vulnerable regions such as their feet, hands and joints. Doctors should look for broken bones, even if the patient feels no pain. Performing X-rays and other imaging tests at sites of possible injury is recommended. An annual skeletal MRI may also be recommended.

Patients are at increased risk of repeated Staphylococcal infections that arise without an obvious external cause. The early use of topical antibacterial creams until all signs of inflammation or infection have resolved has shown to be highly effective in preventing chronic infection.

Some individuals with CIP have a greater incidence of corneal abrasions (eye problem). Management includes at least yearly ophthalmological assessments, regular use of eye lubricants during the day and at night, eye protection in windy or dusty conditions and the avoidance of irritants and chemicals.

Golshani, Ashkahn E., et al. "Congenital Indifference to Pain: An Illustrated Case Report and Literature Review." Journal of radiology case reports 8.8 (2014): 16.

Schon et. al, GeneReviews Congenital Insensitivity to Pain Overview, February 8, 2018

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