Hereditary Diffuse Gastric Cancer

Symptoms

What are the main symptoms of hereditary diffuse gastric cancer?

Symptoms of stomach cancer are generally nonspecific at the early stages. Once symptoms do appear, individuals usually have an advanced stage of the disease. Symptoms in the late stage of gastric cancer may include: nausea, vomiting, abdominal pain, dysphagia (difficulty swallowing), feeling full quickly, loss of appetite, and weight loss.

The types of cancer that are suggestive of hereditary diffuse gastric cancer include: invasive lobular carcinomas, diffuse gastric cancer (also known as signet ring adenocarcinoma of the stomach), intra-mucosal signet ring cell adenocarcinomas of the stomach, and signet ring colon cancer.

Wanebo HJ, Kennedy BJ, Chmiel J, Steele G Jr, Winchester D, Osteen R. Cancer of the stomach. A patient care study by the American College of Surgeons. Ann Surg.1993;218:583–92

Schneider, K. (2013). Counseling About Cancer: Strategies for Genetic Counselors, 3rd Ed.

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