Hereditary Diffuse Gastric Cancer

Healthcare/Doctors

How do I find a center of excellence in hereditary diffuse gastric cancer?

There are several cancer centers who work with individuals with gastric cancer. One example is Johns Hopkins’ Gastric Cancer Center which can be found at: http://www.hopkinsmedicine.org/gastric_cancer_center/treatments_services/hereditary_diffuse.html.

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What specialist doctors should I see with hereditary diffuse gastric cancer?

If I have hereditary diffuse gastric cancer, what should my doctor know about managing the disease?

What specialist doctors should I see with hereditary diffuse gastric cancer?

A gastroenterologist can help manage the stomach screening, and a surgeon is someone you should meet with to discuss the gastrectomy.

References
  • Kaurah P, Huntsman DG. Hereditary Diffuse Gastric Cancer. 2002 Nov 4 [Updated 2014 Jul 31]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015.
If I have hereditary diffuse gastric cancer, what should my doctor know about managing the disease?

Your doctor should also be aware of the signs and symptoms of stomach cancer including: nausea, vomiting, abdominal pain, dysphagia, feeling full quickly, loss of appetite, and weight loss.

Your doctor should be aware of the medical management guidelines found on NCCN.com which include:

  • Prophylactic gastrectomy- recommended after genetic testing results are known, and at age 20 or 5 years prior to the earliest diagnosis in the family
  • Endoscopic surveillance- only done if gastrectomy is not pursued, and multiple random biopsies will be taken. This should be done annually.
  • Breast cancer screening- monthly self-breast exams, biannual clinical breast exams, annual mammograms, and annual MRI’s beginning at age 35
  • Colon cancer screening- colonoscopies every 3-5 years. Begin these at 40 or 10 years younger than the earliest diagnosis in the family.
References
  • Fitzgerald, R. C., Hardwick, R., Huntsman, D., Carneiro, F., Guilford, P., Blair, V., ... & Caldas, C. (2010). Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research. Journal of medical genetics, 47(7), 436-444.
  • Kluijt, I., Siemerink, E. J., Ausems, M. G., van Os, T. A., de Jong, D., Simões?Correia, J., ... & Hoogerbrugge, N. (2012). CDH1?related hereditary diffuse gastric cancer syndrome: Clinical variations and implications for counseling. International Journal of Cancer, 131(2), 367-376.
  • Wanebo HJ, Kennedy BJ, Chmiel J, Steele G Jr, Winchester D, Osteen R. Cancer of the stomach. A patient care study by the American College of Surgeons. Ann Surg.1993;218:583–92

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