Familial adenomatous polyposis

Overview

What is familial adenomatous polyposis?

Familial adenomatous polyposis (FAP) is an inherited condition that runs in the family and causes an increased risk for people who have it to grow many (over one hundred) polyps in their colon. Polyps are abnormal growths of tissue that can turn into cancer if left untreated. The type of polyps found in FAP are called adenomatous polyps. There is also a predisposition for developing other cancers including: small intestinal cancer, pancreatic cancer, thyroid cancer, and hepatoblastoma (tumor of the liver) in children. Having a mutation in the APC genes does not guarantee someone will develop cancer. However, if left untreated, up to 93% of individuals with FAP will develop colon cancer by age 50.

In addition to the standard form of FAP, there are two milder forms of this condition: attenuated familial adenomatous polyposis (AFAP) and MUTYH-associated polyposis (MAP). These forms of FAP are associated with less polyps, but still carry a higher risk of colon cancer than the average person.

References
  • Schneider, K. (2013). , 3rd Ed.
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Are there other names for familial adenomatous polyposis?

What is the usual abbreviation for familial adenomatous polyposis?

Are there other names for familial adenomatous polyposis?

Familial adenomatous polyposis can also be called:

  • Adenomatous familial polyposis
  • Adenomatous familial polyposis syndrome
  • Adenomatous polyposis coli
  • Familial multiple polyposis syndrome
  • FAP
  • MUTYH-associated polyposis

When the colon polyps are found with other very specific health problems, familial adenomatous polyposis can be called Gardner or Turcot syndrome. Gardner syndrome has been used in the past to describe individuals with FAP who also have cysts on their face, desmoid tumors (soft-tissue tumors typically arising in abdomen), extra teeth, or osteomas (cysts on the jaw). Turcot syndrome has been used in the past to describe individuals who with FAP, who also have multiple individuals in their family with CNS (central nervous system) tumors, specifically medulloblastoma, a type of brain tumor.

References
  • Jasperson, K. W. (2017, February 2). APC-Associated Polyposis Conditions. Retrieved from http://www.ncbi.nlm.nih.gov/books/NBK1345/.
  • Nielsen, M. (2019, October 10). MUTYH Polyposis. Retrieved from http://www.ncbi.nlm.nih.gov/books/NBK107219/.
  • Familial adenomatous polyposis - Genetics Home Reference - NIH. (n.d.). Retrieved from http://ghr.nlm.nih.gov/condition/familial-adenomatous-polyposis.
What is the usual abbreviation for familial adenomatous polyposis?

FAP is the abbreviation for familial adenomatous polyposis. The abbreviation for attenuated familial adenomatous polyposis is AFAP. The abbreviation for MUTYH-associated polyposis is MAP.

References
  • Jasperson, K. W. (2017, February 2). APC-Associated Polyposis Conditions. Retrieved from http://www.ncbi.nlm.nih.gov/books/NBK1345/.
  • Schneider, K. (2013). , 3rd Ed.

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