What is the connection between Fabry disease and pirates?
When newborn screening for Fabry disease began Taiwan, the testing found an unexpected high number of babies with a late-onset Fabry-causing pathogenic change or variant in the GLA gene called c.640-801GtoA (also known as IVS4+919GtoA and c.639+919GtoA). Further research in the ancestry of these families found that the gene change was originally brought to the island of Taiwan by a group of seafaring Han Chinese pirates lead by Chief pirate Wang Zhi in the 16th century. It is believed that this group traveled through several ports and countries and expanded the population of individuals with Fabry disease throughout the region.
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Kris E Lane, Kris Lane, Robert M. Levine. Pillaging the Empire: Global Piracy on the High Seas, 1500-1750. Routledge, Jul 24, 2015