What are the first steps after an initial diagnosis of Clouston Syndrome?
After the diagnosis of Clouston syndrome, it is important to identify the person's specific needs. The nails, hair, and skin should be looked at closely. A referral to a dermatologist may be made and a genetics appointment can help with genetic testing for the affected individual and other family members.
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Is there treatment for Clouston Syndrome?
There are treatments for features of Clouston syndrome. They include:
- Artificial nails to improve the appearance of the hands and feet
- Special hair care products to help with dry and sparse hair
- Skin moisturizers for thick skin on the soles of the feet and the palms of the hands
What is the prognosis for Clouston Syndrome?
The prognosis for individuals with Clouston syndrome is positive. The life span is predicted to be normal and there are no developmental concerns.
Is there a cure for Clouston Syndrome?
There is no cure for Clouston syndrome. Treatment is limited to management and surveillance of the features of the condition.
Are any other genetic conditions similar to Clouston Syndrome?
There are other genetic conditions that are similar to Clouston syndrome. Some similar conditions include:
- Hypotrichosis-deafness syndrome. Features of this condition include thin hair, dystrophic nails, and deafness.
- Pachyonychia congenita. Features of this condition include malformed nails, thickened and blistered skin on the palms of the hands and the soles of the feet, white patches on the inside of the tongue and cheeks, bumps on the skin, cysts in specific areas of the body, and excessive sweating on the palms and soles.
- Dominant and recessive forms of hypohidrotic ectodermal dysplasia. Features of these conditions include sparse scalp and body hair, reduced ability to sweat, and absence of teeth.
- van Steensel MA, Steijlen PM, Bladergroen RS, Hoefsloot EH, van Ravenswaaij-Arts CM, van Geel M. A phenotype resembling the Clouston Syndrome with deafness is associated with a novel missense GJB2 mutation. J Invest Dermatol. 2004;123:291–3. PMID: 15245427