Chromosome 1p36 deletion syndrome
How is chromosome 1p36 microdeletion syndrome inherited?
Most cases of chromosome 1p36 microdeletion syndrome are not inherited. These are called "de novo" cases. In these cases, there is no family history. The chromosome deletion happens by itself while the egg or sperm are being made. Sometimes it happens in early development. There is nothing parents can do to cause this deletion. There is nothing parents can do to prevent this deletion. It happens at random.
Chromosome 1p36 microdeletion syndrome is inherited about 30% of the time. Sometimes, a parent has a chromosome problem that can lead to a chromosome 1p36 deletion in their child. This type of problem is called a balanced translocation. In a balanced translocation, a person has all of their chromosomal material, but it is in different places than usual. The parent is not affected because all of their chromosomal material is present. But, when a person with a translocation has children, they are at an increased risk to have a child with too much (duplication) and/or too little (deletion) chromosomal material. Talk to a genetic counselor to learn more about translocations and the risk of passing it on to children. Genetic counselors in the United States can be found on the National Society of Genetic Counselors website. Genetic counselors in Canada can be found at the Canadian Association of Genetic Counselors website.
Battaglia A. 1p36 Deletion Syndrome. 2008 Feb 1 [Updated 2013 Jun 6]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2016.