BRCA2, familial breast-ovarian cancer susceptibility 2

Overview

What is Hereditary Breast and Ovarian Cancer syndrome caused by BRCA2 gene mutations?

Hereditary Breast and Ovarian (HBOC) syndrome is a cancer condition caused by genetic changes in the BRCA1 or BRCA2 genes. Genetic changes in these genes can be passed from parent to child. In other words, HBOC syndrome runs in families. HBOC syndrome is the most common cause of both hereditary breast and hereditary ovarian cancers. People with a genetic change in a BRCA1 or BRCA2 gene have an increased risk for certain types of cancers, including breast, ovarian, prostate, and pancreatic cancers and melanoma. Both men and women can have HBOC syndrome.

SOURCE: Emory University - Department of Human Genetics in collaboration with ThinkGenetic • https://www.thinkgenetic.com/diseases/breast-ovarian-cancer-familial-susceptibility-to-2/overview/5045 • DATE UPDATED: 2016-06-23

References

www.ncbi.nlm.nih.gov/books/NBK1247/

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