BRCA2, familial breast-ovarian cancer susceptibility 2
How is Hereditary Breast and Ovarian Cancer syndrome caused by BRCA2 gene mutations inherited?
We all have two copies of the BRCA2 gene. We inherit one copy from our mother and one copy from our father. BRCA2 is a tumor suppressor gene. When working properly, the BRCA2 genes help to reduce cancer risk. People with Hereditary Breast and Ovarian Cancer (HBOC) syndrome have a gene change (mutation) in one of their BRCA2 genes that causes the gene not to work properly. A nonworking copy of the BRCA2 leads to increased risk for cancer. If a parent has Hereditary Breast and Ovarian Cancer (HBOC) syndrome, there is a 50% chance that each of his or her children will also have HBOC syndrome. This is called autosomal dominant inheritance.