BRCA1, familial breast-ovarian cancer susceptibility 1


How common is Hereditary Breast and Ovarian Cancer syndrome caused by BRCA1 gene mutations?

Hereditary Breast and Ovarian Cancer syndrome is the most common cause of both hereditary breast and hereditary ovarian cancer. Less than 1% of the general population (1 in 400 people) has a genetic change, or mutation, in BRCA1/2, which causes HBOC syndrome. BRCA1/2 mutations are more common in individuals of Ashkenazi Jewish ancestry. More specifically, around 2.5% of people from the Ashkenazi Jewish population (1 in 40 people) carry a BRCA1/2 mutation.

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