BRCA1, familial breast-ovarian cancer susceptibility 1


What is Hereditary Breast and Ovarian Cancer syndrome caused by BRCA1 gene mutations?

Hereditary Breast and Ovarian (HBOC) syndrome is a cancer condition caused by genetic changes in the BRCA1 or BRCA2 genes. Genetic changes in these genes can be passed from parent to child. In other words, HBOC syndrome runs in families. HBOC syndrome is the most common cause of both hereditary breast and hereditary ovarian cancer. People with a genetic change in a BRCA1 or BRCA2 gene have an increased risk for certain types of cancers, including breast, ovarian, prostate, and pancreatic cancers and melanoma. Both men and women can have HBOC syndrome.

Additional and accurate information about HBOC can be found on specific websites including:

1. The "Facing Our Risk of Cancer Empowered" (FORCE) advocacy group's resources for people living with an increased risk of HBOC on their Understanding BRCA and HBOC website.

2. For healthcare providers, an expert summmary on HBOC can be found on the GeneReviews for HBOC.

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