BRCA1, familial breast-ovarian cancer susceptibility 1

Living with

Is it safe for people with BRCA1 gene mutations to use hormone replacement therapy after an oophorectomy and for people with BRCA1 gene mutations?

There is much debate over this question. Use of hormone replacement therapy (HRT) can increase the risk for breast cancer. Many physicians are nervous to prescribe HRT to a woman whose risk for breast cancer is already high. The benefits of HRT after prophylactic oophorectomy can greatly improve quality of life for some women though. Some research has shown that prophylactic oophorectomy reduces the risk for breast cancer even with HRT use. More specifically, one study demonstrated that short-term use of HRT following an oophorectomy did not significantly alter breast cancer risk. There are many factors to discuss with your healthcare provider before deciding whether you should use HRT.

SOURCE: Emory University - Department of Human Genetics in collaboration with ThinkGenetic • https://www.thinkgenetic.com/diseases/brca1-familial-breast-ovarian-cancer-susceptibility-1/living-with/7069 • DATE UPDATED: 2019-07-09

References

http://www.ncbi.nlm.nih.gov/books/NBK1247/

Rebbeck, T.R., Friebel, T., Wagner, T., et al. Effect of short-term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group. J Clin Oncol. 2005; 23: 31: 7804-7810

This content comes from a hidden element on this page.

The inline option preserves bound JavaScript events and changes, and it puts the content back where it came from when it is closed.

Remember Me