BRCA1, familial breast-ovarian cancer susceptibility 1

Causes

What happens because of changes to BRCA1?

Genes act as the instructions for the body. We all have two copies of the BRCA1 gene. We inherit one copy from our mother and one copy from our father. BRCA1 is a tumor suppressor gene. When working properly, the BRCA1 genes help to reduce cancer risk. People with Hereditary Breast and Ovarian Cancer (HBOC) syndrome have a gene change (mutation) in one of their BRCA1 genes that causes the gene not to work properly. A nonworking copy of the BRCA1 leads to increased risk for cancer.

SOURCE: Emory University - Department of Human Genetics in collaboration with ThinkGenetic • https://www.thinkgenetic.com/diseases/brca1-familial-breast-ovarian-cancer-susceptibility-1/causes/7049 • DATE UPDATED: 2019-07-09

References

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