Autosomal dominant polycystic kidney disease

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What is the average life expectancy for someone with autosomal dominant polycystic kidney disease?

Autosomal dominant polycystic kidney disease (ADPKD) can be very different in one person compared to another. It is difficult to make predictions about how the disease will progress. Some people never develop symptoms or only have mild symptoms. There are several factors that determine how severe ADPKD may be including how delayed the diagnosis was and the extent of kidney disease. Most people retain kidney function into their 30s. The rate of progression of kidney decline varies greatly. Some people retain adequate kidney function until very late in life. Risk factors for kidney decline include having a change in the PKD1 gene, younger age of onset of the disorder, increased kidney size, and hypertension. Men and boys are at a greater risk of progressive kidney disease as well. If heart or neurological disease is present, they can cause life-threatening complications.

Talk to your doctor and entire medical team about you or your child's diagnosis and individual prognosis.

Chapman AB, Rahbari-Oskoui FF, Bennett W. Course and treatment of autosomal dominant polycystic kidney disease. UpToDate website.

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