Glucose-6-phosphate dehydrogenase (G6PD) deficiency

Overview

What is G6PD deficiency?

G6PD deficiency is a condition that affects the red blood cells in the body. G6PD stands for glucose-6-phosphate dehydrogenase. Red blood cells have the important job of carrying oxygen throughout the body. If a blood cell has too much oxygen, however, it can harm the cell. G6PD helps to protect the cell from these harmful effects. If someone doesn't have enough G6PD, the red blood cells are unprotected and can break down too early (this is called hemolysis). Hemolysis can lead to anemia (low blood levels). Anemia can cause a number of different issues such as shortness of breath, rapid heart rate, muscle pain, jaundice, and heart attacks. The majority of the time, the anemia in G6PD deficiency is caused by an environmental trigger, such as an infection, certain medications, or eating fava beans. It is possible for someone to have G6PD deficiency and not develop anemia, because they have not been exposed to these triggers.

References
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Are there other names for G6PD deficiency?

How common is G6PD deficiency?

What is the usual abbreviation for G6PD deficiency?

What health problems are part of G6PD deficiency?

Is G6PD deficiency a metabolic disease?

Is G6PD deficiency more common in some parts of the world?

Are there other names for G6PD deficiency?

G6PD deficiency has other, names such as:

  • Glucose-6-phosphate dehydrogenase deficiency
  • Hemolytic anemia due to G6PD deficiency
  • G6PDD
  • Nonspherocytic hemolytic anemia due to G6PD
References
How common is G6PD deficiency?

As of 2018, it is estimated that 400 million people are affected with G6PD deficiency worldwide. In the U.S., it is estimated to affect 1 in 10 African American males. G6PD deficiency is more commonly found in African, Asian, Mediterranean, and Middle Eastern populations. G6PD deficiency is believed to help protect people against malaria, and these areas of the world are prone to outbreaks of malaria. Due to its method of inheritance, G6PD deficiency is almost always seen in males.

References
What is the usual abbreviation for G6PD deficiency?

G6PD stands for glucose-6-phosphate dehydrogenase. G6PD deficiency is having less of the enzyme glucose-6-phosphate dehydrogenase than usual. Sometimes, G6PD deficiency is abbreviated as G6PDD.

References
What health problems are part of G6PD deficiency?

G6PD deficiency is a condition that affects the red blood cells in your body. If someone doesn't have enough of G6PD (an enzyme in the body), the red blood cells can break down prematurely (hemolysis), which can lead to anemia (low levels of blood). Anemia can cause a number of different issues such as shortness of breath, rapid heart rate, muscle pain, jaundice, and heart attacks. The majority of the time, the anemia in G6PD deficiency is caused by an environmental trigger, such as an infection, certain medications, or eating fava beans. It is possible for someone to have G6PD deficiency and not develop anemia, because they have not been exposed to these environmental triggers.

References
Is G6PD deficiency a metabolic disease?

G6PD deficiency is considered a metabolic and a blood disease. A metabolic disease is one where symptoms happen in a person because of the way food or drink is being broken down by their body. A blood disease is one that affects the make up of the blood or how it works. Red blood cells have the important job of carrying oxygen throughout the body. If a blood cell has too much oxygen, however, it can harm the cell. G6PD, an enzyme in the body, helps to protect the cell from these harmful effects. If someone doesn't have enough G6PD, the red blood cells are unprotected and can break down prematurely (hemolysis). Hemolysis can lead to anemia (low blood levels), which can cause a number of different health issues.

References
Is G6PD deficiency more common in some parts of the world?

As of 2018, G6PD deficiency is more commonly found in African, Asian, Mediterranean, and Middle Eastern populations. G6PD deficiency is believed to help protect people against malaria, and these areas of the world are prone to outbreaks of malaria. Due to its method of inheritance, G6PD deficiency is almost always seen in males.

References

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