What is Andersen-Tawil Syndrome?
Andersen-Tawil Syndrome is a genetic condition that causes periods of muscle weakness (periodic paralysis), changes in heart rhythm (arrhythmia), and intellectual and developmental abnormalities. Other features can include low-set ears, widely spaced eyes, small mandible, fifth-digit clinodactyly, syndactyly, short stature, and scoliosis.
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Are there other names for Andersen-Tawil Syndrome?
Andersen-Tawil Syndrome is known by several other names including:
- Andersen Syndrome
- Long QT Syndrome 7
- Andersen Cardioysrhythmic periodic paralysis
What is the usual abbreviation for Andersen-Tawil Syndrome?
The common abbreviation for Andersen-Tawil Syndrome is ATS.
How common is Andersen-Tawil Syndrome?
The prevalence of Andersen-Tawil Syndrome is not known but about 100 people with the condition have been reported worldwide. Andersen-Tawil syndrome is diagnosed in fewer than 10% of individuals with primary periodic paralysis. The incidence of periodic paralysis is also unknown and estimated to be at most 1:100,000.
Are there characteristic physical features associated with Andersen-Tawil Syndrome?
Those with Andersen-Tawil syndrome may have a small lower jaw (micrognathia), dental anomalies including crowded and missing teeth, lower than normal ears, eyes that are widely spaced, and fingers or toes that are unusually curved (clinodactyly). Some people with the condition may be shorter than normal and have an abnormally curved spine (scoliosis).
If you are interested in genetic testing for Andersen-Tawil syndrome, speak with a medical geneticist or genetic counselor to help you obtain testing. A medical geneticist can be found by asking your doctor for a referral or looking on the American College of Medical Geneticists website. Genetic counselors can be found on the National Society of Genetic Counselors website.
Are there psychiatric conditions associated with Andersen-Tawil Syndrome?
There are no known psychiatric conditions associated with Andersen-Tawil Syndrome.