Amyotrophic lateral sclerosis 1


Any other diseases that look a lot like Amyotrophic Lateral Sclerosis?

Many neurodegenerative disorders seem similar in their earlier stages. Studies that can rule out conditions that are similar to amyotrophic lateral sclerosis (ALS) other similar conditions include imaging of brain and/or spinal cord (MRI), blood studies (e.g. CBC, serum concentration of vitamin B12, lead, and TSH), studies of the cerebral spinal fluid (the fluid in the spinal cord that surrounds the nerves) to rule out infection or multiple sclerosis and muscle and/or nerve biopsy.

There are specific hereditary and acquired disorders that are similar to ALS.

Hereditary disorders include:

Spinal and bulbar muscular atrophy (SBMA, Kennedy disease)

ALS8 (also known as SMAIV or Finkel type SMA)

Distal hereditary motor neuronopathy type VIIB

Primary lateral sclerosis (PLS)

Hereditary spastic paraplegia (HSP)

Hexosaminadase A deficiency

Adult polyglucosan body disease

BSCL2-related neurologic disorders

Acquired disorders include:

cervical spine disease

brain stem or spinal cord tumors

thyroid disorders

lead poisoning

vitamin B12 deficiency

multiple sclerosis

paraneoplastic syndrome with occult cancer

motor neuropathies

myasthenia gravis

myasthenic syndrome

inclusion body myositis

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