Amyotrophic lateral sclerosis 1

Overview

What is the difference between Limb-Onset Amyotrophic Lateral Sclerosis and Bulbar-Onset Amyotrophic Lateral Sclerosis?

Limb-onset amyotrophic lateral sclerosis (ALS) is when initial signs and symptoms are weakness in the hands/feet or loss of balance. Most people experience limb-onset ALS. Bulbar-onset ALS is when initial signs and symptoms are slurring words/having trouble talking clearly. 25% of people with amyotrophic lateral sclerosis have bulbar-onset ALS. The first area of symptoms does not appear to correlate with a specific cause of ALS.

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