Amyotrophic lateral sclerosis 1


How is Amyotrophic Lateral Sclerosis inherited?

Changes in several genes have been reported to cause familial amyotrophic lateral sclerosis (ALS), which are inherited. ALS can be inherited in three different ways: autosomal dominant, autosomal recessive and X-linked dominant. In autosomal dominant forms of ALS only one of the two copies of the gene need to have a disease-causing change. Individuals with a parent with dominant ALS have a 50% chance to develop the disease. In the autosomal recessive forms of ALS, both copies of the gene must have a disease-causing change. Autosomal recessive cases only occur when both parents have a genetic variation and both pass it on to a child. In X-linked dominant ALS, both men and women are affected but the gene can not be passed from male to male.

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