Amyotrophic lateral sclerosis 1
What gene changes cause Amyotrophic Lateral Sclerosis?
Changes in several genes have been reported to cause familial amyotrophic lateral sclerosis (ALS). Some forms of ALS are autosomal dominant, in which only one of the two copies of the gene need to have a disease-causing change. Others are autosomal recessive and both copies of the gene must have a disease-causing change.
These genes have been reported to cause autosomal dominant familial ALS:
These genes have been reported to cause autosomal recessive familial ALS:
Variants in the UBQLN2 gene have been reported to call X-linked dominant familial ALS. In these cases, both men and women are affected but the gene can not be passed from male to male.