Amyotrophic lateral sclerosis 1

Causes

What gene changes cause Amyotrophic Lateral Sclerosis?

Changes in several genes have been reported to cause familial amyotrophic lateral sclerosis (ALS). Some forms of ALS are autosomal dominant, in which only one of the two copies of the gene need to have a disease-causing change. Others are autosomal recessive and both copies of the gene must have a disease-causing change.

These genes have been reported to cause autosomal dominant familial ALS:

SOD1

SETX

FUS/TLS

VAPB

ANG

TARDBP

FIG4

C9orf72

CHCHD10

VCP

TBK1

These genes have been reported to cause autosomal recessive familial ALS:

ALS2

OPTN

SPG20

Variants in the UBQLN2 gene have been reported to call X-linked dominant familial ALS. In these cases, both men and women are affected but the gene can not be passed from male to male.

OMIM

http://www.ncbi.nlm.nih.gov/books/NBK1450/

This content comes from a hidden element on this page.

The inline option preserves bound JavaScript events and changes, and it puts the content back where it came from when it is closed.

Remember Me