Alzheimer disease

Causes

What genetic changes cause early onset familial Alzheimer Disease?

The PSEN1, APP, and PSEN2 genes cause early onset familial Alzheimer Disease (AD). PSEN1 is responsible for 30% to 70% of early onset familial AD. APP gene causes 10% to 15% of early onset familial AD. PSEN2 causes less than 5% of early onset familial AD. Most genetic changes are small changes that are found through DNA sequence analysis(reading through the gene looking for a spelling mistake). Large deletions (missing pieces of the gene) or duplications (extra pieces of the gene) in the genes are less common.

This content comes from a hidden element on this page.

The inline option preserves bound JavaScript events and changes, and it puts the content back where it came from when it is closed.

Remember Me