Alzheimer disease

Causes

What genetic changes cause early onset familial Alzheimer Disease?

The PSEN1, APP, and PSEN2 genes cause early onset familial Alzheimer Disease (AD). PSEN1 is responsible for 30% to 70% of early onset familial AD. APP gene causes 10% to 15% of early onset familial AD. PSEN2 causes less than 5% of early onset familial AD. Most genetic changes are small changes that are found through DNA sequence analysis(reading through the gene looking for a spelling mistake). Large deletions (missing pieces of the gene) or duplications (extra pieces of the gene) in the genes are less common.

We use cookies to ensure that we give you the best experience on our website. By continuing to browse this site, you are agreeing to our use of cookies.

Continue Find out more about our use of cookies and similar technology

This content comes from a hidden element on this page.

The inline option preserves bound JavaScript events and changes, and it puts the content back where it came from when it is closed.

Remember Me