Alpha-1-antitrypsin deficiency

Living with

Will I die from alpha-1 antitrypsin deficiency?

Individual outcomes vary significantly for people with alpha-1 antitrypsin deficiency (AATD). A person's signs and symptoms are a better predictor of prognosis than their AATD diagnosis alone. Some people with AATD live a normal lifespan with no symptoms of the disease. Many live a normal lifespan, with symptoms of the disease, if symptoms are detected early and treated properly. Avoiding smoking increases the chances for a good outcome. People who have severe lung disease or severe liver disease may face life-threatening complications, and may die due to end stage organ disease without an organ transplant. Ages of onset of lung disease are most commonly 30-40s in smokers and 50s or later in nonsmokers. Liver disease can occur in people of any age, but is more common in infants and adults over age 40. Talk to your doctor about your personal health and outlook.

Alpha-1 Foundation. Retrieved from

UpToDate. Clinical manifestations, diagnosis, and natural history of alpha-1 antitrypsin deficiency. Retrieved from

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