How is Alagille syndrome inherited?
Alagille syndrome is inherited in an "autosomal dominant" manner. We each typically have twp copies of every gene in our body. Genes provide instructions to our cells to make the items that our bodies need to grow and function. When there is a change or spelling mistake (also known as a mutation) in a gene, that gene may not work as well as it is supposed to or may not work at all. "Autosomal dominant" inheritance means that a change in one of the two copies of the gene involved in Alagille syndrome is enough to cause the condition. Since we pass on one copy of each gene to our children when we have babies, a person with Alagille syndrome has a 50% chance of passing on the genetic change causing the condition to each of their children.
Alagille Syndrome. GeneReviews. https://ghr.nlm.nih.gov/condition/alagille-syndrome
Alagille Syndrome. Genetics Home Reference. https://ghr.nlm.nih.gov/condition/alagille-syndrome