Adrenoleukodystrophy

Inheritance

What are the risks to the children of a man with X-linked adrenoleukodystrophy?

Males have one X and one Y chromosome. All the daughters of a male with X-linked adrenoleukodystrophy will inherit the ABCD1 gene that isn't working properly because that is the only X chromosome a male has to pass on. That daughter would most likely inherit a normally functioning ABCD1 gene from her mother, and therefore she would be a carrier. Most carriers do not show symptoms of the condition. If they do show symptoms, these symptoms are less severe than those of a male. Sons of a male with X-linked adrenoleukodystrophy will have no risk of inheriting the condition, because they do not receive their father's X chromosome, only his Y chromosome.

X-Linked Adrenoleukodystrophy. Genetics Home Reference. Updated July 2013.https://ghr.nlm.nih.gov/condition/x-linked-adrenoleukodystrophy

Steinberg, S., Moser, A., Raymond, G. X-Linked Adrenoleukodystrophy. Gene Reviews. Online database. Updated April 2015. http://www.ncbi.nlm.nih.gov/books/NBK1315/

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