How is X-linked adrenoleukodystrophy inherited?

X-linked adrenoleukodystrophy is inherited in an X-linked manner, because the ABCD1 gene is located on the X chromosome. Women who are carriers for X-linked adrenoleukodystrophy have a 50% chance of passing the changed ABCD1 gene to each of their children. If a daughter inherits the change, she too will be a carrier, or mildly affected. If a son inherits the change he will likely exhibit full symptoms of X-linked adrenoleukodystrophy. Men who have X-linked adrenoleukodystrophy will not pass their genetic change on to any of their sons, but all of their daughters will be carriers.

X-Linked Adrenoleukodystrophy. Genetics Home Reference. Updated July 2013.

Steinberg, S., Moser, A., Raymond, G. X-Linked Adrenoleukodystrophy. Gene Reviews. Online database. Updated April 2015.

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