Are changes in the ABCD1 gene a predisposition or a cause?
Changes in the ABCD1 gene in males are considered causative, not a predisposition, for X-linked adrenoleukodystrophy, including the cerebral form, adrenomyeloneuropathy, and the Addison-disease only form. This being said, symptoms and the age that those symptoms begin can vary between individuals and some boys and men may not realize they have the gene change.
X-Linked Adrenoleukodystrophy. Genetics Home Reference. Updated July 2013.https://ghr.nlm.nih.gov/condition/x-linked-adrenoleukodystrophy