Acyl-coa dehydrogenase, medium-chain, deficiency of

Inheritance

How is medium-chain acyl-CoA dehydrogenase deficiency (MCAD) inherited?

Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is inherited in an autosomal recessive manner. This is one way a disorder or trait can be passed down through a family. Everyone has two copies of the ACADM gene; one received from their father and one from their mother. Autosomal recessive inheritance means that a person receives a nonworking copy of the ACADM gene from both parents. The parents have one working copy of the gene and one nonworking copy; they are carriers for MCAD deficiency. Carriers do not develop symptoms of the disorder. If two people who are carriers have MCAD deficiency, there is a 25% chance with each pregnancy that the child will have the disorder and a 50% chance the child will also be a carrier for the disorder. If you have a family member with MCAD deficiency and you would like to know if you are a carrier, talk to your doctor or meet with a genetic counselor to discuss testing options. Genetic counselors can be found on the National Society of Genetic Counselors website.

References
Show More Content Like This

More Inheritance Content

How likely is medium-chain acyl-CoA dehydrogenase deficiency to be passed on in a family?

How likely is medium-chain acyl-CoA dehydrogenase deficiency to be passed on in a family?

We each get two copies of most of our genes from our parents. One copy comes from our mother and the other copy comes from our father. In medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, both parents must pass along a nonworking copy of the ACADM gene. Because of this, MCAD deficiency is inherited in what is called an autosomal recessive pattern. People who have one working and one nonworking copy of the ACADM gene are called carriers. When both parents are carriers, for each individual pregnancy, there is a 25% chance that both parents will pass along a nonworking copy of the gene and the child will have the disorder. There is a 50% chance that one parent will pass on the gene change and the other will not, meaning the child will be a carrier for the disorder. Finally, there is a 25% chance that both parents will pass along a working copy of the gene and the child will not have the disorder and will not be a carrier. If you are interested in finding out if you are a carrier for MCAD deficiency, talk to your doctor about testing or contact a genetic counselor in your area. Genetic counselors can be found on the National Society of Genetic Counselors website.

References

We use cookies to ensure that we give you the best experience on our website. By continuing to browse this site, you are agreeing to our use of cookies.

Continue Find out more about our use of cookies and similar technology

This content comes from a hidden element on this page.

The inline option preserves bound JavaScript events and changes, and it puts the content back where it came from when it is closed.

Remember Me