Acromegaly

Inheritance

If someone in my family has acromegaly, how can I find out if I am at risk?

Most cases of acromegaly do not have a know genetic cause. However, in rare cases, acromegaly can be found to run in families. In some individuals with acromegaly an AIP gene change is found that causes that person to be at increased risk to develop a tumor. Based on the type of tumor, the age the tumor was diagnosed in a family member, and other factors, genetic testing of the AIP gene may be useful to help identify other family members who are at increased risk to develop acromegaly. Your doctor can help you understand if you are at increased risk for having a genetic change in the AIP gene and may want to pursue genetic testing. Your doctor may also want to refer you to a medical geneticist or genetic counselor to discuss your risk further. A medical geneticists can be found by asking your doctor for a referral or looking on the American College of Medical Geneticists website. Genetic counselors can be found on the National Society of Genetic Counselors website.

Caimari et al., J Med Genet. 2018 Apr; 55(4): 254-260. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869708/

This content comes from a hidden element on this page.

The inline option preserves bound JavaScript events and changes, and it puts the content back where it came from when it is closed.

Remember Me