Acromegaly

Inheritance

How is acromegaly inherited?

Current data suggests that most cases of isolated acromegaly are not due to an underlying hereditary (genetic) cause that gets passed through a family. However, when acromegaly begins in childhood or adolescence the gene aryl hydrocarbon receptor interacting protein, AIP, is thought to be a susceptibility factor. It is also suspected when many people in the family are affected. We are still learning more about this gene and its associated risks.

Sometimes acromegaly is seen as part of other genetic conditions. For example, those with multiple endocrine neoplasia (MEN1) or Carney Complex can develop acromegaly. But this is due to the underlying genetic cause for those conditions and not due to an isolated event.

"Acromegaly" National Institute of Diabetes and Digestive and Kidney Diseases. April 2012. https://www.niddk.nih.gov/health-information/health-topics/endocrine/acromegaly/Pages/fact-sheet.aspx#common

"Acromegaly" ORPHA963. Orphanet http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=963

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